Grape plants have been used in traditional treatment for ages. Besides being a wellspring for vitamins and fiber, the skin and seeds of grapes are highly rich in Polyphenols specifically proanthocyanidins, which can be used as a functional ingredient to address various health issues by boosting the natural bio-processes of the body.

GSE shows anti-inflammatory, anti-apoptotic, anti-necrotic, cardiovascular and anti-carcinogenic activity and has beneficial effects against several diseases including skin aging. It also shows a positive effect on wound healing. The presence of antioxidant properties in GSE has been shown to exert a much stronger oxygen-free radical-scavenging effect. Compounds those are having antioxidant properties able to protect the cells against oxidative stress. The antioxidant property of proanthocyanidin is because of the availability of the phenolic-hydrogens as singlet oxygen quenchers and hydrogen-donating radical scavengers. It can then act as an inflammatory reaction regulator (related to oxidative stress), hence, controlling the oxidative stress. The use of GSE decreases oxidative stress and helps in the reduction of anti-inflammation.